Box plots showing the EZH2 expression ratios obtained in CD34+ cells of 174 MDS cases without 7q LOH and 17 healthy controls. A significant down-regulation of expression was identified for EZH2 in excess of blasts subgroups. NML indicates normal controls; 5q-, 5q-syndrome; RA, refractory anemia; RARS, refractory anemia with ring sideroblasts; RCMD, refractory anemia with multilineage dysplasia; and RAEB, refractory anemia with excess of blasts.