Photomicrographs illustrating the different steps during the enucleation process. The nucleus is first displaced to one side of the erythroblast (left panel). A contractile actin ring is then formed to begin to pinch off the nascent reticulocyte from the nucleus (middle panel). Subsequent redistribution of membrane between the 2 lobes of the dividing cell by vesicle shuttling further restricts the area of contact between the 2 emerging cells (right panel). Images courtesy of Dr Marcel Bessis.