Defective mechanically induced thrombus formation and impaired hemostasis in RhoA^−/− mice. (A-C) The abdominal aorta of wt and RhoA^−/− mice was injured by tight compression with a forceps, and blood flow was monitored for 30 minutes. Time to stable vessel occlusion (A) and representative blood flow curves (B) are shown. Each symbol represents 1 individual. (C) Representative H&E–stained cross sections of the abdominal aorta of wt and RhoA^−/− mice 30 minutes after injury. Scale bar represents 200 μm. (D) Defective hemostasis in RhoA^−/− mice. Tail bleeding times of wt and RhoA^−/− mice in saline at 37°C. Each symbol represents 1 individual.