RhoA^−/− mice are protected from cerebral ischemia. Formation of cerebral brain infarction and consequential neurologic defects were investigated in a murine stroke model of tMCAO. (A) Brain infarct volumes in wt (n = 24) and RhoA^−/− mice (n = 14) presented as mean ± SD (left). Representative images of 3 corresponding coronal sections from wt and RhoA^−/− mice stained with 2,3,5-triphenyltetrazolium chloride 24 hours after tMCAO. Infarcted areas are marked with arrows (right). Bederson score (B) and grip test (C) determined 24 hours after tMCAO (*P < .05; **P < .01).