Figure 5
Expression of hFVII in young rhesus monkeys following fetal administration of vector supernatant andreadministration postnatally. (A) Plasma human FVII levels in young rhesus monkeys following administration of 4 × 1011 vg/kg scAAV5-LP1-hFVII-coop prenatally and scAAV8-LP1-hFVII-coop at 1 year postnatal age. (B) Anti-AAV5 IgG levels in plasma after fetal administration of AAV5 LP1 hFVII coop. (C) Anti-AAV8 IgG levels following administration of scAAV8-LP1-hFVII-coop (second administration of vector) in monkeys at 1 year postnatal age.
