Mice with megakaryocyte-specific gene targeting of TGF-β1 have better preservation of systolic function than WT mice. (A) EF, (B) FS, (C) Vcf_c, and (D) SV were calculated from echocardiographic measurements in WT and Tgfb1^flox mice before (basal) and 1 and 4 weeks after TAC surgery. Total TGF-β1 levels at 1 week after surgery were inversely correlated with (E) FS and (F) Vcf_c.