A TLR3 SNP is associated with increased risk of invasive aspergillosis in HSCT recipients. The TLR3 +95C/A genotypes of 223 consecutive hematologic patients undergoing allogeneic HSCT and their respective donors were determined by the bidirectional PCR amplification of specific alleles (Bi-PASA) method and correlated with the incidence of invasive aspergillosis. (A) Cumulative incidence of invasive aspergillosis at 12 months according to patient +95C/A genotype: CC (22.2%, n = 123) and CA + AA (19.9%, n = 66); P = .70 (B) Cumulative incidence of invasive aspergillosis at 12 months according to donor +95C/A genotype: CC (14.8%, n = 109) and CA + AA (30.2%, n = 80); P = .01.