Lack of effect of hydroxyurea on pneumococcal pneumonia in E-selectin deficient SCA mice. (A) Mean overall survival of E-selectin–deficient (triangles; n = 9; WT indicates wild-type), E-selectin–deficient/SCA mice treated with saline (circles; n = 21), and E-selectin–deficient/SCA mice treated with hydroxyurea (squares; n = 18). Mice were challenged with 3 × 106 CFUs in 25 μL saline. No significant difference (Mantel-Cox log rank test, P = .744) was observed between the E-selectin–deficient/SCA mice untreated versus treated with hydroxyurea. (B) Log CFUs/mL of bacteria in blood of mice in panel A at 24 hours after challenge. Each symbol is a mouse, and the bar is the mean. — indicates limit of detection. The asterisk indicates a statistically significant difference compared with SCA saline group (P = .03 for survival, P = .003 for blood titers).
