Effect of recombinant ANXII infusion and L-methionine supplementation in leukemic mice. (A) tPA levels increased with both 1 and 10 μg/kg doses of ANXII, but no difference was observed between the 2 dosage groups. TAT was higher in mice that received 10 μg/Kg of ANXII. (B). Effect of L-methionine administration on tPA (C) and TAT (D) levels.