PAS for platelet calcium mobilization for 3 separate donors. For Donors 1-3, calcium traces were measured in the presence of low, medium, and high doses of ADP, U46619, and convulxin (CVX) in the presence or absence of iloprost and simulated by NN (A). The normalized synergy parameters (−1 ≤ S ≤ 1) for all measured pairs (± iloprost) was calculated for each donor as well as for the donor-specific NN-simulated calcium responses under identical conditions (B). Measured and NN-simulated synergy values were highly correlated, indicating successful training of the NN models (C).