Multiscale simulation of patient-specific platelet deposition under flow. Platelet activation (in all subplots: black indicates inactivated and white, fully activated) and deposition at 500 seconds (inlet wall shear rate, 200/s) for Donor 1 in the presence of released ADP (A) and TXA2 (B) in which the local shear rate near the platelet deposit varied markedly from less than 50/s to greater than 1000/s (C). Flow: left to right (streamlines; black lines); surface collagen (250 μm long): red bar. The background color of each subplot represents the state of a single, representative simulation at 500 seconds for the concentrations of ADP (A) and TXA2 (B) and the local fluid shear rate (C). The activation state (ξ) of each platelet and the morphology of the surface is the same across all subplots.
