Comparison of microfluidic experiments and multiscale simulations of platelet deposition. Measured platelet deposition dynamics for 3 donors in the presence of aspirin, indomethacin, MRS 2179, and iloprost (A) and the corresponding donor-specific multiscale simulations with no TXA2 (indomethacin or aspirin), no ADP (MRS 2179), and iloprost treatment (B). Comparison of measured (C) and simulated (D) platelet deposit mass at 500 seconds for Donors 1-3. Shading for time series data in panels A and B shows SD. Experiment: control, n = 24, n = 22, and n = 22 for Donors 1, 2, and 3, respectively; aspirin, n = 8; indomethacin, n = 8; MRS 2719, n = 8; and iloprost, n = 14. Simulation: n = 16 for all conditions and donors. *P < .01 relative to control for each donor.
