Model for the regulation of DC development by PGE₂. In this model, we propose that PGE₂ signaling through the PGE₂ G protein EP1 and EP3 receptors regulates Flt3 expression on DC-committed progenitors (CDPs and pre-cDCs) and modifies downstream phopho-STAT3 activation and survivin expression. Elevated survivin expression protects DC progenitors from caspase-3–mediated apoptotic death and results in optimal DC development.