Prior administration of oral THU increases oral bioavailability and decreases interindividual variability in pharmacokinetics of DAC. (A) DAC concentration-time profiles in 8 baboons administered oral DAC 200 mg/m² (10 mg/kg). (B) DAC concentration-time profiles in the same 8 baboons administered DAC at half the dose (100 mg/m² [5 mg/kg]) 60 minutes after THU 400 mg/m² (20 mg/kg; THU-DAC). PK measurements went to 180 instead of 240 minutes because of the allowable duration of anesthesia. (C) The largest increases in AUC_last with coadministration of THU were seen in animals with lower intrinsic oral bioavailability of DAC. Histograms show the distribution of AUC_last in 7 animals administered DAC alone versus the same 7 animals receiving DAC at half the dose after THU. AUC measurements went to 180 instead of 240 minutes in the THU-DAC group because of the allowable duration of anesthesia.