Time to tolerance by median peak inhibitor titres. (A) Kaplan-Meier plot showing the time to tolerance of all 115 randomized, treated subjects categorized according to peak historical titer above and below the median 22 BU/mL value (P = .006). (B) Kaplan-Meier plot showing the time to tolerance of all 115 randomized, treated subjects categorized according to peak inhibitor titer on ITI above and below the median 36 BU/mL value (P = .001).