Model describing the putative role of EGFL7 in Notch signaling in different vascular beds. (A) EGFL7 signaling in the postnatal retina. EGFL7 antagonizes Notch/ligand interaction by either binding to the receptor or its corresponding ligand and inhibits target gene expression. (B) EGFL7 signaling in the embryo. EGFL7 indirectly enhances DLL4/Notch signaling by binding to Jagged1, preventing an interaction with the glycosylated Notch receptor, and promoting DLL4 interaction with Notch. ECD indicates extracellular domain; and NICD, Notch intracellular domain.