Expression and functional significance of B7 antigens and HLA-G on plasma cells. (A) Expression of CD80, CD86, HLA-G, CD273, CD274, and CD275 on BM plasma cells (CD38⁺⁺) of patients with myeloma. (B) Overall survival of patients according to HLA-G expression on BM plasma cells with HLA-G expression > 12% (HLA-G–positive) and < 12% (HLA-G–negative; χ² = 12.4; P < .0004). (C) Overall survival of patients who had CD86 positive n = 33) and CD86 negative plasma cells (n = 28; χ² = 6.5; P < .01) at diagnosis with CD86 positivity defined as > 60% (the upper limit of CD86 expression on normal plasma cells).