Platelet counts in thymocyte-treated ITP mice. (A) Platelet counts in control SCID mice transferred with 1.5 × 104 splenocytes from naive BALB/c mice (N = 5, ●) or SCID mice transferred with 105 thymocytes from either SCID ITP mice (N = 5, □) or SCID ITP mice treated biweekly with 2 g/kg IVIg (N = 15, ♢). (B) Platelet counts in SCID mice transferred with 1.5 × 104 splenocytes from CD61 immune KO mice (SCID ITP, N = 5, ○) or SCID mice transferred with 105 thymocytes from SCID ITP mice 5 days before receiving splenocytes from CD61 immune KO mice (N = 5, ▵) or SCID mice transferred with 105 thymocytes from SCID ITP mice treated with IVIg 5 days before receiving splenocytes from CD61 immune KO mice (N = 5, ▿). Thrombocytopenia at day 7 occurred in all irradiated mice as previously described.11 The data are expressed as platelet counts (× 109/L; mean ± SEM) over time (days). The solid horizontal lines represents the normal mean platelet count (± SEM; hatched lines) from 250 healthy SCID mice (mean ± SD platelet count = 720 ± 41). (B) *P < .01, the SCID mice administered thymocytes (▵) and control ITP SCID mice (○).
