Both phospholipase Cβ3 and phospholipase Cγ have similar enzymatic activities in cleavage of PIP2 into diacylglycerol and Ins (1,2,4) triphosphate. Diacylglycerol activates canonical protein kinase C, while Ins (1,2,4) triphosphate binds to its receptor IP3R, resulting in calcium release. Loss of phospholipase Cβ3 results in activation of stat5 and possibly reactive oxygen in the face of unopposed phospholipase Cγ, resulting in proliferation and increased vascular permeability. Structure of PIP2 from Wikipedia.¹⁰