Vascular endothelial growth factor receptor 2 (VEGFR2) signalosome. Within the cell membrane, VEGFR2 is associated with several co-receptors such as neuropilin-1 (NRP1), CD146, and CD44v6, together representing the so-called VEGFR2 signalosome. Co-receptors enable efficient ligand binding to VEGFR2 by their extracellular domains. Furthermore, their cytoplasmic tail binds ezrin-radixin-moesin (ERM) proteins that recruit cytoskeletal elements that function as scaffold for VEGFR2 downstream mediators. Depending on the combination of VEGFR2 with its co-receptors, VEGFR2 may cause activation of diverging downstream signaling cascades resulting in discriminative biologic processes.