Effects of LDE223 on GVL and survival in the P815 leukemia model. (A-B) In mice injected with 500 (A) or 1500 (B) P815 cells, comparable survival times were noted in LDE223-treated, allogeneically transplanted mice and sham-treated, allogeneically transplanted mice. (C) Injection of 10 000 cells P815 led to death of all mice within 16 days. No survival advantage of allogeneically transplanted mice was detectable in mice injected with 10 000 tumor cells, and survival did not differ between LDE223-treated mice and sham-treated mice. Survival over time is shown as Kaplan-Meier curves. Nine mice per group were analyzed.