Leukocyte accumulation is dependent onLFA-1/ ICAM-1 interactions. Leukocyte (blue) accumulation at site of injury (white arrow) in absence (top panel) or presence (bottom panel) of (B) ICAM-1 or (C) LFA-1 blocking antibody. Graph represents medians of Mac-1–integrated fluorescence intensity before (upper curve, 33 thrombi; 3 mice) and after (lower curve, 31 thrombi; 3 mice) infusion of (B) ICAM-1 or (C) LFA-1–blocking antibody.