Neutrophils activate the coagulation TF pathway leading to thrombus and fibrin formation. (A) Platelet accumulation at the site of injury in wild-type mice in absence or presence of ICAM-1–blocking antibody (32 thrombi, 3 mice for each condition). Graph represents medians of platelet-integrated fluorescence intensity in presence or absence of ICAM-1–blocking antibody over time. (B) Fibrin generation in wild-type mice in presence or absence of ICAM-1–blocking antibody. Graph represents medians of fibrin-integrated fluorescence intensity in WT mice in presence (28 thrombi in 3 mice) or absence (40 thrombi in 3 mice) of ICAM-1–blocking antibody over time.