Allogeneic transfer of BM and low concentrations of splenic cells in hosts treated with Cy/TBI-caused cGVHD and BO. B10.BR mice treated with 120 mg · kg−1 · d−1 Cy (day −3, −2) and lethally irradiated (day −1) were transplanted with BM alone or BM plus 0.75-1 × 106 splenocytes from C57Bl/6 mice. n = 10 mice/group. Weights of the animals (A) and survival (B) were tracked up to 60 days after transplantation. PFTs were performed on anesthetized animals at day 60 (C) and day 28 (D) after transplantation. Animals were artificially ventilated, and resistance, elastance, and compliance were measured as parameters of distress in lung function in animals receiving low-dose splenocytes or T cells. Representative data from 3 individual experiments. **P < .01.
