Current treatment of multiple myeloma. (A) Newly diagnosed and (B) relapsed. *Or similar bortezomib-based triplet. **Bortezomib may be preferred for intermediate- and high-risk patients. †Consider salvage ASCT in patients eligible for ASCT. ‡Any of the regimens listed for first relapse that the patient has not previously been exposed to. ASCT, autologous stem cell transplantation; DRD, daratumumab, lenalidomide, dexamethasone; DVD, daratumumab, bortezomib, dexamethasone; ERD, elotuzumab, lenalidomide, dexamethasone; IRD, ixazomib, lenalidomide, dexamethasone; KRD, carfilzomib, lenalidomide, dexamethasone; PD, pomalidomide plus dexamethasone. Rd, lenalidomide, dexamethasone; VCD, bortezomib, cyclophosphamide, dexamethasone; VRD, bortezomib, lenalidomide, dexamethasone.