PLCβ3 null mice exhibit greater VEGF-induced VP than wild-type mice. (A-B) VEGF-induced VP was evaluated in wild-type and PLCβ3–null mice (n = 5/group). FITC signal, normalized to t0, is shown for subdermal PBS control and VEGF injections. The average fold change in signal after injection for wild-type (A) and PLCβ3 (B) mice. Representative ear images from 10 and 30 minutes after injection are shown in the panels on the right. Maximum induction mean for PLCβ3 was 3.319 ± 0.7385 versus wild-type, 1.518 ± 0.1187 (P = .0468). Error bars represent SD.