Figure 3
![Figure 3. Inhibition of miR-27a/b impairs angiogenesis in mice. (A-B) Effect of systemic infusion of 3 intravenous injections (each 12 mg/kg body weight) at day 0, day 2, and day 4 of antagomirs targeting miR-27a and miR-27b (AM-27a/b) or a control antagomir (AM-Co; n = 4-8 mice per group, 2 plugs/mouse) on miR expression in hearts, aorta, muscles, or Matrigel plugs harvested 7 days after the first injection. (C-D) Effect of antagomir infusion on the number of lectin-perfused vessels in Matrigel plugs in vivo after 7 days (n = 8 mice per group, 2 plugs/mouse: n = 15 plugs [AM-Co] and n = 16 plugs [AM-27a/b]). *P < .05 versus AM-Co. Representative images are shown in panel C.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/119/6/10.1182_blood-2011-08-373886/5/zh89991285880003.jpeg?Expires=1735565957&Signature=hkO9W4kF0ucXJG3ZT8nLntPK47iN7rndOrN9~3kRErR4x54OLeHI710s4gTOalxCQzyxCSqZkkl~JLBO3znnTgGZLzK3tReOH9jAkGdFPKgYul5qrtKmc-nZN8DHyhd8c5wfqTHbcwa7Hk7atvd0-FjtVq-a2He2De~OUHzAJLOZAfuTcAo839KlPkpY6zt-t6bcubb1qp~5xGIUSo0I9FWSj5RQTs8xQLPbITfaxXHORL85NN5EUYvs8roKgZ0z0QlaU2PWdicLwcbwAWixqAW~7wjdLCXzxcCqGSiVD~l39hS3Dyp4oyhxGrADKzAYjGTW5jQPx1ewj-2p3Bw-6g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Inhibition of miR-27a/b impairs angiogenesis in mice. (A-B) Effect of systemic infusion of 3 intravenous injections (each 12 mg/kg body weight) at day 0, day 2, and day 4 of antagomirs targeting miR-27a and miR-27b (AM-27a/b) or a control antagomir (AM-Co; n = 4-8 mice per group, 2 plugs/mouse) on miR expression in hearts, aorta, muscles, or Matrigel plugs harvested 7 days after the first injection. (C-D) Effect of antagomir infusion on the number of lectin-perfused vessels in Matrigel plugs in vivo after 7 days (n = 8 mice per group, 2 plugs/mouse: n = 15 plugs [AM-Co] and n = 16 plugs [AM-27a/b]). *P < .05 versus AM-Co. Representative images are shown in panel C.
