LZ/DZ-related pathways underlie the distinction between molecular subgroups in aggressive mature B-NHL. (A) Consensus clustering (1000 bootstraps) of the aggressive mature B-NHL case series described by Hummel et al,²⁰  according to the expression pattern of the common human/mouse signature (1.5-fold cutoff; supplemental Figure 4; supplemental Table 4). Shown is the clustering image with k = 2 (no significant improvement of the CDF was observed with higher k values). (B) Distribution of mBL and non-mBL cases, as defined by Hummel et al,²⁰  among the 2 different subgroups identified by the consensus clustering analysis shown in panel A. The P value shown refers to the significance of the distribution of the 3 subclasses in Hummel et al²⁰  (mBL, intermediate, non-mBL) among each class (DZ-like or LZ-like; χ² test). (C) GSEA plots illustrating the enrichment for mBL and non-mBL classifier gene signatures (as defined by Hummel et al²⁰ ) in human LZ and DZ GC B-cell gene expression data. Nominal and adjusted P values and false discovery rate are all below the detection level (< .001) for both comparisons.