The combination of anti-CD146 AA98 and anti-VEGF bevacizumab has cumulative antitumor effects on human pancreatic carcinoma growth and angiogenesis in vivo. (A) Representation of human pancreatic carcinoma in xenografted mice. (B) Mean tumor volumes at specific time points after injection of human pancreatic carcinoma cells SW1990 (n = 10). (C) When tumor size reached approximately 3 cm³, mice were killed and tumors were excised and weighed. Tumor weight was evaluated and is shown in the graphs. (D) Microvascular density of tumors. Sections from human pancreatic carcinoma were stained with anti-CD31 Ab (scale bar indicates 100 μm). Statistical significance was calculated with the unpaired Student t test. *P < .05; **P < .01; ***P < .001.