Ratio of CD8⁺ to CD4⁺ or Tregs over time. (A) Median ratios of CD8⁺:CD4⁺ (left; n = 58) and CD8⁺:Tregs (right; n = 38) increased at weeks 8 and 16 compared with baseline in the PB. Only patients with baseline, week 8, and week 16 measurements were included. (B) Similarly, in BM, median ratios of CD8⁺:CD4⁺ (left) and CD8⁺:Tregs (right) increased on treatment (week 12 ± 1 cycle) compared with baseline. No significant differences were observed between responders and nonresponders.