Effect of daratumumab treatment on T-cell clonality. Patients with pre- and posttreatment samples were evaluated (n = 17). TCR clonality (A) increased during treatment with daratumumab and (B) was correlated with increases in CD8⁺ T cells. The sum of absolute CIA in responders and nonresponders is shown (C) for each expanded T-cell clone and (D) maximum CIA of a single T-cell clone. NR, nonresponder; R, responder.