Figure 2
Figure 2. KIR+ CD8 T cells display a restricted TCR Vβ chain repertoire. The distribution of 24 specific TCR Vβ chains were analyzed in distinct CD8 T-cell subsets in samples from 20 individuals homozygous for the group A KIR haplotype. (A) TCR Vβ chain distribution in KIR− CD45RA+CD27+CD57− (Naïve), KIR− CD45RA+CD27−CD57+ (EMRA), and panKIR+ CD45RA+CD27−CD57+ (EMRA) CD8 T cells summarized for all analyzed individuals. (B) TCR Vβ chain distribution in panKIR+ CD45RA+CD27−CD57+ (EMRA) CD8 T cells and within the largest (KIR+ 1) and second largest (KIR+ 2) KIR-expressing subsets of CD45RA+CD27−CD57+ (EMRA) CD8 T cells summarized for all analyzed individuals. (A-B) ***P < .001, **P < .01, paired t test. (C) TCR Vβ chain repertoires of the 2 largest KIR-expressing subsets of CD45RA+CD27−CD57+ CD8 T cells shown for 4 representative individuals. The dominant TCR Vβ chains are indicated in the respective bar graphs.

KIR+ CD8 T cells display a restricted TCR Vβ chain repertoire. The distribution of 24 specific TCR Vβ chains were analyzed in distinct CD8 T-cell subsets in samples from 20 individuals homozygous for the group A KIR haplotype. (A) TCR Vβ chain distribution in KIR− CD45RA+CD27+CD57− (Naïve), KIR− CD45RA+CD27−CD57+ (EMRA), and panKIR+ CD45RA+CD27−CD57+ (EMRA) CD8 T cells summarized for all analyzed individuals. (B) TCR Vβ chain distribution in panKIR+ CD45RA+CD27−CD57+ (EMRA) CD8 T cells and within the largest (KIR+ 1) and second largest (KIR+ 2) KIR-expressing subsets of CD45RA+CD27−CD57+ (EMRA) CD8 T cells summarized for all analyzed individuals. (A-B) ***P < .001, **P < .01, paired t test. (C) TCR Vβ chain repertoires of the 2 largest KIR-expressing subsets of CD45RA+CD27−CD57+ CD8 T cells shown for 4 representative individuals. The dominant TCR Vβ chains are indicated in the respective bar graphs.

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