Genetic alterations in AA. (A) Somatic mutations and other genetic lesions in AA. Mutations and CNAs indicated on the left are shown for individual patients (shown horizontally). Frequency of each genetic lesion is presented on the right. (B) Frequency of mutations in AA, MDS, and ARCH, according to the reports from Yoshizato et al,¹⁸  Haferlach et al,⁶⁶  and Jaiswal et al,²⁰  respectively, for which the denominators are the total numbers of mutations in each report. ARCH, age-related CH; CHIP, CH with indeterminate potential; NIH, National Institutes of Health.