Inhibition of myelopoiesis using a dual c-Fms/c-Kit inhibitor attenuates inflammation and bone destruction in cmo mice. (A) Time course of disease progression in cmo mice receiving the c-Fms/c-Kit inhibitor, PLX3397 (PLX), or control chow. Treatment was started at 5 weeks of age, before the onset of clinical symptoms and continued up to ∼ 8 months of age (WT, 252 ± 18 and cmo 248 ± 19 days), at which time the mice were euthanized and analyzed. (B-C) Micro CT reconstruction of distal tails (B) and hind paws (C) of PLX-treated and control cmo mice. (D) PLX treatment decreases circulating MIP-1α in cmo mice. (E) Quantitative bone parameters of PLX-treated and control cmo and WT mice. (F) Micro CT reconstructions of proximal tibiae. (G-H) PLX treatment of cmo mice prevents splenomegaly (G) and the expansion of splenic OCP (H). Scale bars, 100 μm. Data ± SEM, n ≥ 3.