Protein and protein-subdomain localization of mutations/indels in genes previously undescribed in CLL or associated with prognosis. x-axis: length of the protein in amino acids (aa); y-axis: number of mutations at a given protein position. Blue boxes represent important subdomains or motifs of each protein (modified according to MutationMapper v1.0.1).⁵²  Red pins, nonsense or frameshift alterations; green pins, missense mutations; black pins, in-frame alterations.