The inactivation of p53 decreases the survival of NHD13⁺ Tg mice with MDS or AML. (A) Kaplan-Meier survival curves for the NHD13⁺ (n = 23), NHD13⁺p53^+/− (n = 25), NHD13⁺p53^−/− (n = 18) mice with MDS or AML, and the p53^+/− (n = 24), p53^−/− (n = 23) control mice are shown. The P value represents the comparison of survival between the NHD13⁺p53^−/− and p53^−/− mice, or a comparison of survival between NHD13⁺p53^+/− and p53^+/− mice (***P < .001). (B) Survival curves for the NHD13⁺ (n = 23), NHD13⁺p53^+/− (n = 25), and NHD13⁺p53^−/− (n = 18) mice with MDS or AML. The P value represents a comparison of survival between the NHD13⁺p53^−/− and NHD13⁺ mice, or between the NHD13⁺p53^+/− and the NHD13⁺ mice (***P < .001). (C) Survival curves for the NHD13⁺ (n = 7), NHD13⁺p53^+/− (n = 14), and NHD13⁺p53^−/− (n = 10) mice with MDS. The P value represents the comparison of survival between NHD13⁺p53^−/− and NHD13⁺ MDS mice (***P < .001). (D) Survival curves for the NHD13⁺ (n = 16), NHD13⁺p53^+/− (n = 11), and NHD13⁺p53^−/− (n = 8) mice with AML. The P value represents a comparison of survival between NHD13⁺p53^−/− and NHD13⁺ mice, or between NHD13⁺p53^+/− and NHD13⁺ mice (***P < .001).