PFS and OS of patients with high-risk cytogenetics with arms B and C, respectively. High-risk cytogenetics is defined as the presence of deletion 17p and/or t(4;14). (A) OS of arm B vs arm C in patients without high-risk cytogenetics. (B) PFS of arm B vs arm C in patients without high-risk cytogenetics. (C) OS of arm B vs arm C in patients with high-risk cytogenetics. (D) PFS of arm B vs arm C in patients with high-risk cytogenetics.