Retroviral transduction/transplantation assays with the use of RUNX1(Ala224fsTer228) or RUNX1(41-214). (A) Schematic representation of full-length RUNX1b, RUNX1(Ala224fsTer228), and RUNX1(41-214). Numbers represent amino acid numbering, based on the human RUNX1 isoform b. (B) Kaplan-Meier survival curve of animals transplanted with control vector (MigR1; n = 17), RUNX1(Ala224fsTer228) (n = 12), and RUNX1(41-214) (n = 15) of 4 independent sets of experiments. TA indicates transcriptional activation domain; and BMT, bone marrow transplantation.