Molecular responses of CML-CP patients, by treatment arm and approximate time on study. Changes of BCR-ABL mRNA level, relative to group-specific median baseline values, are shown on a common log (log₁₀) scale for patients randomized to DAS (solid line) or IM (dashed line) therapy. Boxplots showing the 25th and 75th percentiles are connected at the median values (IM, blue; DAS, red). Horizontal dashed lines indicate no change, 3-log and 4-log reduction from baseline. Month 3: days 43-126; month 6: days 127-210; month 9: 211-294; month 12: days 295-420.