Cloning of the of the t(X;14)(p11;q32) translocation breakpoint in MALT lymphoma. (A) Sequence of the t(X;14)(p11;q32) breakpoint. DNA sequence from Xp11.4 is shown in gray and IGHA2 in black. (B) Chromosomal location of the breakpoints on chromosome 14 and X and the structure of der.¹⁴  Idiogram Album: copyright 1994 David Adler. (C) Interphase FISH analysis of the t(X;14) index case. In the left panel the Xp11.4 BAP probe shows a 1R2G1F pattern, indicative of splitting of Xp11.4 as well as an extra copy of the distal (green) Xp arm. In the middle panel the IGH BAP probe shows a 2R1G1F pattern, consistent with the presence of 2 translocations, the first occurring within the typical IGH breakpoint region (indicated by 1 red and 1 green signal) and the second occurring proximally to the typical IGH breakpoint (indicated by 1 red and 1 fusion signal). In the right panel the t(X;14)(p11.4;q32) dual fusion probe shows a 1R1G3F signal pattern. (D) Array CGH analysis of tumor cells from the t(X;14) patient, showing an extra copy of the distal portion of chromosome X up to the position of the Xp11.4 BAP FISH probe. (E) Predicted gene organization of der.¹⁴