High expression of GPR34 distinguishes a unique molecular subset of MZLs and correlates with GPR82 and SOX11 expression. (A) GEP data from NMZBL tumors (n = 34) was used to classify GPR34 high and low-expressing tumors. High is defined as those tumors that express GPR34 at levels greater than 2 standard deviations above the mean of the normal controls. (B) Heatmap of GPR34 high and low expressing NMZBCL tumors. (C) Table of 10 most up-regulated and down-regulated genes in GPR34 high tumors. (D) Correlation of GPR34 expression with GPR82 and SOX11 in MZL (n = 83).