Patterns of TP53 mutations in 506 cases of DLBCL patients treated with R-CHOP. (A) Proportion of classified point mutations. (B) Proportion of mutations based on mutation impact on the p53 protein sequence. (C) Proportion of mutations based on mutation effect on the p53 function. (D) Distribution of mutation numbers according to TP53 exons. The numerals at the top are numbers of mutations in exons, and the numerals at the bottom are numbers of mutations in splicing sites. (E) Codon distribution of TP53 mutations. Codons with mutations of high frequency in the cohort are marked. See Figure 1 in the article by Xu-Monette et al that begins on page 3986.