β2-glycoprotein I changes conformation on antibody binding. Scanning electron microscopy images showing plasma β2-GPI (A) and β2-GPI in complex with antibodies against domain I of β2-GGI (B). Samples were visualized using a Jeol JEM 1230 transmission electron microscope operated at 60 kV accelerating voltage and recorded with a Gatan Multiscan 791 CCD camera using the software provided by the manufacturer (magnification 200 000×).