ERG identifies genomic regions important in hematopoietic development and has cell type specific binding profiles. (A) Schematic representation of normal and aberrant hematopoietic differentiation. HSC indicates hematopoietic stem cells; and LSC, leukemic stem cells. (B) Overview of the OGG1, CAMK1, and SPI1 ERG binding sites in normal CD34⁺ cells and ERG and AML1-ETO (AE) binding sites in blast cells from a patient with t(8;21). Yellow represents the ERG ChIP-seq data; and blue, the AML1-ETO data. (C) Heatmap display of motif scores of DNA sequences underlying ERG binding sites in normal CD34⁺ cells. (D) Venn diagram representing the overlap of ERG (pz12) and the common AML1-ETO binding sites of t(8;21) patient AML cells and ERG binding sites in normal CD34⁺ cells. (E) Venn diagram representing the overlap of ERG binding sites in normal CD34⁺ cells, t(15;17) APL cells, and t(8;21) AML patient cells (pz12). (F) Number of RUNX1 motifs present in t(8;21) patient ERG binding sites not occupied by AML1-ETO (left) or present in AML1-ETO binding sites (right).