Computational simulation of the meizothrombin pathway. All coagulation factors and inhibitors are set to their mean physiologic levels. Thrombin generation was initiated with a hypothetical 5pM Tf stimulus. (A) αTAT (■) and mTAT (■) species. (B) Empirical αTAT data from Figure 1C (●) and Figure 1D were used to derive αTAT species originating through the mIIa pathway (○).