Pharmacokinetics and pharmacodynamics of IPH2101. (A) Mean concentration-time profiles of anti-KIR (IPH2101). The mean concentration-time profiles of anti-KIR (IPH2101) after IV infusion of dose levels of 0.003, 0.015, 0.075, 0.3, 1, and 3 mg/kg are depicted on a semilog scale. The lowest dose level (0.0003 mg/kg) was not displayed on the graph because of a limited number of concentrations above the lower limit of quantification (5 ng/mL). When only one concentration was measurable (other concentrations below the lower limit of quantification) at a given nominal time point, the mean was not displayed on the graph. (B) KIR saturation after IPH2101 treatment. KIR occupancy by IPH2101 was based on the detection of free KIR with PE-IPH2101. Percentage KIR occupancy is the ratio of staining with PE-IPH2101 at the indicated time after treatment compared with the predose staining. N indicates number of patients; and E, number of events. Statistical analyses were performed 1, 7, 14, and 28 days after infusion.