Patterns of TP53 mutations in 506 DLBCL patients treated with R-CHOP. (A) Proportions of classified point mutations. (B) Proportions of mutations based on mutation impact on the p53 protein sequence. (C) Proportions of mutations based on mutation effect on the p53 function. (D) Distribution of mutation numbers according to TP53 exons. The numerals on top are numbers of mutations in exons, and the numerals at the bottom are numbers of mutations in splicing sites. (E) Codon distribution of TP53 mutations. Codons with mutations of high frequency in the cohort are marked.