Figure 6
Active incorporation of iMK-derived human platelets into thrombi. Similar studies were done as described in Figure 5, but panels A and B are whole human blood studied on the collagen chip. Panel B has been exposed to 50 μg/mL anti–human CD42b antibody HIP1 for 20 minutes before study. (C) Similar to panel B but whole human blood has been exposed to an isotype control antibody. (D) Representative collagen chip thrombus study from NOG mice postinfusion with 5 × 105 iMKs per mouse exposed to HIP1 as in panel B. A 50 μm bar is shown in bottom right corner of each image.
