Platelet-ovarian cancer signaling pathways and potential therapeutic targets. Interleukin-6 secreted by ovarian cancer cells stimulates hepatic thrombopoietin (TPO) production, which drives thrombopoiesis in the bone marrow and thrombocytosis. TGFβ secreted from platelets interacts with cancer cells to increase proliferation. Also shown are potential targets for modulating these interactions. Modified from Stone at al.7 Professional illustration by Paulette Dennis.
