Genomic alterations in pBL. (A) Diagram of mutations identified by targeted genomic sequencing. Columns represent individual samples. Alterations listed include only those likely to be somatic as referenced in COSMIC,²²  as well as MYC point mutations and indels of unknown significance. We detected copy number alterations by comparing targeted genomic DNA sequence coverage with a process-matched normal control sample. We detected genomic rearrangements by clustering chimeric reads mapping to targeted introns. (B) Distribution of frequency of alterations by EBV status. EBV-negative cases (EBV Neg) are significantly more likely to have > 1 alteration compared with EBV-positive cases (EBV Pos; P < .0001).